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A. Original Articles

  1. Kume K, Shimizu T, Seyama Y: Characterization of sn-glycerol 3-phosphate acyltransferase from guinea pig harderian gland microsomes. J. Biochem. 101: 653-60, 1987
  2. Okazaki K, Okazaki N, Kume K, Jinno S, Tanaka K, Okayama H: High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by trans-complementation of Schizosaccharomyces pombe. Nucleic Acids Res. 18: 6485-9, 1990
  3. Kume K, Jinno S, Miwatani H, Kizaka-Kondoh S, Terada Y, Nojima H, Okayama H: Oncogenic signal-induced ability to enter S phase in the absence of anchorage is the mechanism for the growth of transformed NRK cells in soft agar. New Biol. 4: 504-11, 1992
  4. Mutoh H, Kume K, Sato S, Kato S, Shimizu T: Positive and negative regulations of human platelet-activating factor receptor transcript 2 (tissue-type) by estrogen and TGF-beta 1. Biochem. Biophys. Res. Commun. 205: 1130-6, 1994
  5. Ferby IM, Waga I, Sakanaka C, Kume K, Shimizu T: Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils. J. Biol. Chem. 269: 30485-8, 1994
  6. Izumi T, Honda Z, Mutoh H, Kume K, Shimizu T: Regulation and signal transduction of PAF receptor. Adv. Prostaglandin Thromboxane Leukot. Res. 23: 461-6, 1995
  7. Yokomizo T, Ogawa Y, Uozumi N, Kume K, Izumi T, Shimizu T: cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. J. Biol. Chem. 271:2844-50, 1996
  8. Sato S, Kume K, Takano T, Mutoh H, Taketani Y, Shimizu T: Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. Adv. Exp. Med. Biol. 416:95-100, 1996
  9. Ferby I, Waga I, Kume K, Sakanaka C, Shimizu T: PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. Adv. Exp. Med. Biol. 416:321-6, 1996
  10. Mori M, Aihara M, Kume K, Hamanoue M, Kohsaka S, Shimizu T: Predominant expression of platelet-activating factor receptor in the rat brain microglia. J. Neurosci. 16:3590-600, 1996
  11. Ishii S, Matsuda Y, Nakamura M, Waga I, Kume K, Izumi T, Shimizu T: A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages. Biochem. J. 314 ( Pt 2):671-8, 1996
  12. Waga I, Kume K, Ferby I, Honda Z, Shimizu T: Micro-trap phosphorylation assay of mitogen-activated protein (MAP) kinases to detect their activation by lipopolysaccharides. J. Immunol. Methods 190:71-7, 1996
  13. Ferby IM, Waga I, Hoshino M, Kume K, Shimizu T: Wortmannin inhibits mitogen-activated protein kinase activation by platelet-activating factor through a mechanism independent of p85/p110-type phosphatidylinositol 3-kinase. J. Biol. Chem. 271:11684-8, 1996
  14. Yokomizo T, Ogawa Y, Uozumi N, Kume K, Izumi T, Shimizu T: cDNA cloning and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. Adv. Exp. Med. Biol. 407:151-6, 1997
  15. Kume K, Shimizu T: cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase. Biochem. Biophys. Res. Commun. 237:663-6, 1997
  16. Ishii S, Nakamura M, Waga I, Kume K, Izumi T, Shimizu T: Cloning and characterization of a murine platelet-activating factor receptor gene. Adv. Exp. Med. Biol. 407:347-55, 1997
  17. Uozumi N, Kume K, Nagase T, Nakatani N, Ishii S, Tashiro F, Komagata Y, Maki K, Ikuta K, Ouchi Y, Miyazaki J, Shimizu T: Role of cytosolic phospholipase A2 in allergic response and parturition. Nature 390:618-22, 1997
  18. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y: Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am. J. Physiol 272(1 Pt 1):G16-22, 1997
  19. Ishii S, Nagase T, Tashiro F, Ikuta K, Sato S, Waga I, Kume K, Miyazaki J, Shimizu T: Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J. 16:133-42, 1997
  20. Mori M, Aihara M, Kume K, Hamanoue M, Kohsaka S, Shimizu T: Localization of platelet-activating factor receptor in the rat brain. Adv. Exp. Med. Biol. 407:357-63, 1997
  21. Kume K, Waga I, Shimizu T: Microplate chromatography assay for acetyl-CoA: lysoplatelet-activating factor acetyltransferase. Anal. Biochem. 246:118-22, 1997
  22. Tabuchi S, Kume K, Aihara M, Ishii S, Mishina M, Shimizu T: Lipid mediators modulate NMDA receptor currents in a Xenopus oocyte expression system. Neurosci. Lett 237:13-6, 1997
  23. Kume K, Shimizu T: Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J. Biol. Chem. 272:22898-904, 1997
  24. Kinoshita S, Suzuki H, Ito K, Kume K, Shimizu T, Sugiyama Y: Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells. Pharm. Res. 15:1851-6, 1998
  25. Hirabayashi T, Kume K, Shimizu T: Conditional expression of the dual-specificity phosphatase PYST1/MKP-3 inhibits phosphorylation of cytosolic phospholipase A2 in Chinese hamster ovary cells. Biochem. Biophys. Res. Commun. 253:485-8, 1998
  26. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y: Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. J. Biol. Chem. 273:1684-8, 1998
  27. Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T, Sugiyama Y: Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats. Mol. Pharmacol. 53:1068-75, 1998
  28. Shimada A, Ota Y, Sugiyama Y, Sato S, Kume K, Shimizu T, Inoue S: In situ expression of platelet-activating factor (PAF)-receptor gene in rat skin and effects of PAF on proliferation and differentiation of cultured human keratinocytes. J. Invest. Dermatol. 110:889-93, 1998
  29. Ishii S, Kuwaki T, Nagase T, Maki K, Tashiro F, Sunaga S, Cao WH, Kume K, Fukuchi Y, Ikuta K, Miyazaki J, Kumada M, Shimizu T: Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med. 187:1779-88, 1998
  30. Kobayashi K, Ishii S, Kume K, Takahashi T, Shimizu T, Manabe T: Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region. Eur. J. Neurosci. 11:1313-6, 1999
  31. Hirabayashi T, Kume K, Hirose K, Yokomizo T, Iino M, Itoh H, Shimizu T: Critical duration of intracellular Ca2+ response required for continuous translocation and activation of cytosolic phospholipase A2. J. Biol. Chem. 274:5163-9, 1999
  32. Nagase, T, Ishii, S, Kume, K, Uozumi, N, Izumi, T, Ouchi, Y, Shimizu, T: Platelet-activating factor mediated acid-induced lung injury in genetically-engineered mice. J. Clin. Invest. 104, 1071-6, 1999
  33. Sato, S, Kume K, Ito, C, Ishii S, Shimizu T: Accelerated proliferation of the epidermal keratinocytes by the transgenic expression of the platelet-activating factor receptor. Arch. Dermatol. Res. 291, 614-21, 1999
  34. Kume K, Zylka MJ, Sriram S, Shearman LP, Weaver DR, Jin X, Maywood ES, Hastings MH, Reppert SM: mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98:193-205, 1999
  35. Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K Lee CC, Van der Horst GTJ, Hastings MH, Reppert SM: Interactiving molecular loops in the mammalian circadian clock. Science 288:1013-19, 2000
  36. Nagase T, Uozumi N, Ishii S, Kume K, Izumi T, Ouchi Y, Shimizu T: Acute lung injury by sepsis and acid aspiration: a key role of cytosolic phospholipase A2. Nature Immunol. 1:42-46, 2000
  37. Aihara M, Ishii, S, Kume K, Shimizu T: Interaction between neuron and glia mediated by platelet-activating factor. Genes to Cells 5:397-406, 2000
  38. Tabuchi S, Kume K, Aihara M, Shimizu T: Expression of lysophosphatidic acid receptor in rat astrocytes: Mitogenic effect and expression of neurotrophic genes. Neurochem. Res 25:573-582, 2000
  39. Nakatani N, Uozumi N, Kume K, Murakami M, Kudo I, Shimizu T : Role of cytosolic phospholipase A2 in the production of lipid mediators and histamine release in mouse bone-marrow-derived mast cells. Biochem. J. 352(Part 2):311-317,
  40. Kawasawa Y, Kume K, Nakade S, Haga H, Izumi T, Shimizu T: Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Biochem. Biophys. Res. Commun. 276:952-956, 2000
  41. Kawasawa Y, Kume K, Izumi T, Shimizu T: Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression. Biochem. Biophys. Res. Commun. 276:957-964, 2000
  42. Yamashita A, Kawagishi N, Miyashita T, Nagatsuka T, Sugiura T, Kume K, Shimizu T, Waku K : ATP-independent fatty acyl-coenzyme A synthesis from phospholipid: coenzyme A-dependent transacylation activity toward lysophosphatidic acid catalyzed by acyl-coenzyme A:Lysophosphatidic acid acyltransferase. J. Biol. Chem. 276: 26745-26752, 2001
  43. Morales J, Hiesinger PR, Schroeder AJ, Kume K, Verstreken P, Jackson FR, Nelson DL, Hassan BA : Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34: 961-972, 2002
  44. Hegen M, Sun L, Uozumi N, Kume K, Goad ME, Nickerson-Nutter CL, Shimizu T, Clark JD : Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis. J. Exp. Med. 197: 1297-1302, 2003
  45. Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, Sehgal A: Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J. Biol. Rhythms 18: 12-25, 2003
  46. Kodama S, Toyonaga T, Kondo T, Matsumoto K, Tsuruzoe K, Kawashima J, Goto H, Kume K, Kume S, Sakakida M, Araki E: Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Biochem. Biophys. Res. Commun. 327: 1170-1178, 2005
  47. Kume K, Kume S, Park SK, Hirsh J, Jackson FR: Dopamine is a regulator of arousal in the fruit fly. J. Neurosci. 25: 7377?7384, 2005

B. Case Report

  1. Nakamura N, Kume K, Mori M, Namiki M: Portal hypertension in chronic lymphocytic leukemia. Jpn. J. Clin. Hematol. 30: 2169-72, 1989
  2. Kume K, Nakamura N, Mori M, Nakazawa S, Enomoto Y, Namiki M: Acute myelomegakaryocytic leukemia developed from myelodysplastic syndrome after chemotherapy against complicated small cell lung cancer. Jpn. J. Clin. Hematol. 32: 261-5, 1991

C. Review Article

  1. Mori M, Bito H, Sakanaka C, Honda Z, Kume K, Izumi T, Shimizu T: Activation of mitogen-activated protein kinase and arachidonate release via two G protein-coupled receptors expressed in the rat hippocampus. [Review] Ann N Y Acad Sci 744: 107-25, 1994
  2. Yokomizo T, Uozumi N, Takahashi T, Kume K, Izumi T, Shimizu T: Leukotriene A4 hydrolase and leukotriene B4 metabolism. [Review] J Lipid Mediat Cell Signal 12: 321-32, 1995
  3. Shimizu T, Mori M, Bito H, Sakanaka C, Tabuchi S, Aihara M, Kume K: Platelet-activating factor and somatostatin activate mitogen-activated protein kinase (MAP kinase) and arachidonate release. [Review] J Lipid Mediat Cell Signal 14:103-8, 1996
  4. Kume K, Shimizu K, Ishii S: Study of platelet activating factor by using mouse ontogenic technology. Jpn. J. Clin. Immunol. 19:572-5, 1996
  5. Jackson FR, Schroeder AJ, Roberts MA, McNeil GP, Kume K, Akten B : Cellular and molecular mechanisms of circadian control in insects. [Review] J. Insect Physiol. 47: 833-842, 2001

D. Invited Speech

  1. Kume K., and Shimizu T.: Structure and Function of Platelet-activating Factor Receptor. The 4th International Congress on Platelet-activating Factor and Related Lipid Mediators. Salt Lake City, USA, 1992
  2. Shimizu, T., Honda, Z., Sakanaka, C., Takano, T., Kume, K., Mutoh, H., Bito, H., Waga, I., Ferby, I., and Izumi, T.: MAP kinase activation by platelet-activating factor receptor/G-proteins. 12th International Congress of Pharmacology (IUPHAR) 1994
  3. Kume, K., and Shimizu, T. : Platelet-activating Factor and Cellular Growth and Transformations. The 5th International Congress on Platelet-activating Factor and Related Lipid Mediators. Berling, Germany 1996
  4. Kume, K., and Shimizu, T.: Temporal and special specific expression of a transgene with Tetracycline-regulator system. Japan-France Neuroscience Colloquium, Strasbourg, France 1997